The Black Water Mist had belonged to Garlic, but following Garlic's imprisonment and death, Kami hid it at The Lookout. When Garlic Jr. takes over Kami's Lookout, he finds and releases the Black Water Mist. Anyone who breathes in the mist has the evil in their heart drawn out and becomes a demon-like vampire, and worships Garlic Jr. and the Spice Boys. In addition, anyone bitten by one infected by the mist becomes exactly like them. If kept unchecked, the Black Water Mist's effects would be irreversible after twenty-four hours. The only thing that can negate the Black Water Mist is the Sacred Water. However, even the Sacred Water will be useless after 24 hours.
- When Piccolo was infected with the mist, it didn't have an effect on him, because Namekians are immune to the mist (though if they are, it contradicts Spice's line "Piccolo's Namekian body is having a strong reaction to the venom" although this appears more as an observation rather than a fact, and he could be mistaken).