In her timeline, her husband Future Goku died of his heart disease and cannot be wished back to life with the Dragon Balls, due to his death being a natural cause. As she cried and mourned the loss of her husband, the Earth is dominated by the Androids, all of the Z Fighters (excluding Future Gohan) are killed by Androids 17 and 18 and because of Future Piccolo's death, the Dragon Balls disappear forever as all of the Z Fighters are unable to be wished back which also kills Kami. Future Chi-Chi is one of the very few survivors. A few years after Goku's death, Chi-Chi is shown at the age of 43 and still lives in her house on Mount Paozu, with her father Future Ox-King still visiting her often. She eventually loses her 23-year-old son, Future Gohan (her only son in this timeline) to the Androids. Chi-Chi looks to be extremely depressed and sad in this timeline, most likely due to the fact that Goku was killed by the incurable heart virus and that her only son Gohan was constantly battling and eventually was killed by the androids. She managed to stay alive from the androids, most likely because her house is hidden in the mountains, away from major cities the androids seemed target.
However it is unknown if she survived when Goku Black invaded because Future Trunks stated there's hardly any humans alive in his timeline.