The entire list of all characters who are killed by Piccolo.
- Raditz – Goku held Raditz in place, while Piccolo charged up and fired a Special Beam Cannon, mortally wounding Raditz and killing Goku. Piccolo later finished Raditz off while he was laughing at him.
- Goku – Shot through the chest with a Special Beam Cannon, killing him and mortally wounding his brother and enemy, Raditz. Goku was later revived with the Dragon Balls.
- Saibaman – Killed by Piccolo with the Explosive Breath Cannon.
- Sansho – Piccolo smashed the demon into the wall and finished him with an energy blast.
- Slug's soldiers – Most of them are killed by Gohan and Piccolo.
- Wings – Piccolo broke Wings' arm, then later shot an energy blast at his head, blowing it clean off.
- Dore – As Gohan left to take the Senzu Beans to Goku, Dore chased after him, so Piccolo fired a Chasing Bullet at Dore that followed him around. Dore eventually tried to block it, but was unable to, and was destroyed.
- Neiz – Neiz electrocuted Piccolo, but Piccolo, while electrified, grabbed onto Neiz's head, electrocuting him and killing him.
- Salza – Salza was about to kill Goku and the others, weakened from battle, when Piccolo shot a Special Beam Cannon through him, killing him.
- Lord Slug – After the Destron Gas Generator is destroyed, Piccolo kills Slug with an energy wave.
- Lord Slug – In the movie Dragon Ball Z: Lord Slug, Piccolo gives all of his energy to Goku, allowing him to use Kaio-ken x100 to attack the Super Namek, as Goku uses the attack, Piccolo overshadows him.
- Hatchiyack – Only in the 2010 remake of Plan to Eradicate the Super Saiyans, Piccolo kills Hatchiyack by combining the Special Beam Cannon with the Super Kamehameha, Final Flash, Burning Attack and Super Masenko done by Goku, Vegeta, Trunks and Gohan.
- Kid Buu – Provided his energy to Goku's Super Spirit Bomb along with the rest of the inhabitants Earth, which Goku used to destroy the pure evil Majin.
- Piccolo has killed all members of Cooler's Armored Squadron.