One day, Mr. Satan and the master of the Satan Castle were on tour in South City. At a bar, Satan and his martial-arts master made the mistake of making fun of Mercenary Tao's hairstyle. As a result, the master of the Satan Castle was killed and Mr. Satan was heavily injured.
South City is mentioned in the movie Dragon Ball Z: The World's Strongest when Dr. Kochin tells Bulma that he and Dr. Wheelo turned a vast forest area near South City into a wasteland in a flash using some of Dr. Wheelo's "brillant scientific techniques".
It was later mentioned by Future Trunks to Goku that the battle with the androids would take place on an island south west of it, Amenbo Island. In the Dragon Ball Z episode "Our Hero Awakes", a news report mentions Cell attacking the city.